Mohamed Salah's penalty failed to save Egypt as World Cup hosts Russia all-but secured progression from Group A with a comprehensive 3-1 win in St Petersburg.
Making his first appearance since going off injured in the Champions League final on May 26, Salah was often on the periphery at the Krestovsky Stadium, but still managed to mark his World Cup debut with a consolation on 73 minutes.
However, the damage had already been done in a 15-minute blitz from Russia early in the second half, Ahmed Fathy's own-goal opening the floodgates.
Russia took full advantage of the moment of good fortune, Denis Cheryshev and Artem Dzyuba netting in the space of three minutes to put Russia in complete control.
Despite his struggles, Salah was rewarded for his resilience when he was fouled by Roman Zobnin - VAR overturning the referee Enrique Caceres's initial decision to award a free-kick on the edge of the area.
The Liverpool star duly converted from the spot but it could not kick-start a comeback, and while Russia's place in the last 16 will be confirmed should Uruguay beat Saudi Arabia, Egypt look set to fall out at the first hurdle.
Russia wasted no time in carrying on where they left off in their opening victory - Sergei Ignashevich heading at Mohamed El-Shenawy before Aleksandr Golovin fired wide.
Egypt weathered the storm, though, and Trezeguet very nearly took advantage of the extra space created by Salah's presence when he curled just wide from the edge of the box.
Cheryshev went close to taking his tally for the tournament to three moments later, but El-Shenawy ensured the winger's strike did not dip in under the crossbar.
Salah's moment looked set to arrive in the 34th minute, but Yuri Zhirkov ensured he was in the right place to prevent the forward connecting with Mohamed Shafy's deflected cross.
Zhirkov could do nothing to prevent Salah's next effort, however, as he spun clear of the experienced defender and sent a wicked strike inches wide of the target.
19 - Mohamed Salah has had fewer touches than any other Egyptian outfield player in the first half against Russia. Search. pic.twitter.com/beR9WklLng— OptaJohan (@OptaJohan) June 19, 2018
Any Egypt momentum was punctured two minutes into the second half, though.
El-Shenawy's poor punch put Egypt under pressure, and Zobnin's first-time follow up spun in off the unfortunate Fathy, with VAR confirming that Dzyuba had not fouled his opponent.
Salah was presented with a glorious chance to restore parity with 56 minutes gone, only to hesitate, allowing Mario Fernandes to intervene.
Fernandes soon made a key contribution at the other end too, driving into the box before supplying a neat cut-back for Cheryshev to slot home Russia's second.
Dzyuba got in on the act with a fantastic turn and finish to send the crowd into raptures, though Zobnin's clumsy pull-back at least enabled Salah to get himself a World Cup goal.
Still, his effort came in a losing cause for Egypt, with the hosts making it two wins from two to close in on a place in the next round.
|Diamondbacks rout Cubs to remain in postseason picture|
|Modric embraces Ballon d´Or chants as Di Francesco backs Madrid star for award|
|MLS Review: Martinez helps Atlanta stage comeback amid VAR controversy|
|Kerevi recommits to Wallabies, Reds|
|Lyon to ban fan for life after footage of Nazi salute emerges|
|Milan must respect opponents – Gattuso not underestimating Dudelange|
|Copa Libertadores Review: Zarate leads Boca, River draw|
|Mourinho: Dalot can play at Man United for more than 10 years|
|Johnson hoping to erase East Lake demons|
|´No question´ Fitzgerald faces Bears, says Cardinals´ Wilks|
|Rodgers says roughing the passer penalties are ´going the wrong direction´|
|Ravens fined $200,000 for violating communication policy|
|LeBron James set to star in ´Space Jam´ sequel|
|Ronaldo red card ´absurd´, says Pjanic|
|Kovac hails ´special´ Sanches after Bayern goal|
|Marcelino: Tearful Ronaldo said he did nothing wrong|
|Fernandinho takes blame for Man City´s Lyon loss|
|Lovren denies any wrongdoing after perjury charge|
|Plzen boss Vrba slams late mistakes|
|I almost scored as many as Messi - Tagliafico the unlikely hero for Ajax|
|Ronaldo deserves Ballon d´Or not Modric, says Casemiro|
|United fan Rafael - I´ve never lost at City|
|Davis explains abrupt mid-game NFL retirement: ´Football is not for me´|
|Lopes pays tribute to under-fire Lyon coach Genesio|
|Toulon´s Bastareaud handed five-week ban|
|Steelers WR Brown disciplined for missing meeting|
|Arteta refuses to make excuses for Manchester City´s Lyon loss|
|Allegri calls for VAR after Ronaldo´s contentious red card|
|Championship Review: Boro go second, Birmingham still winless|
|Lopetegui: Mariano took his chance|
|Juventus proved their quality after Ronaldo red card - Bonucci|
|Pogba ´class´ impresses Mourinho|
|Man City not Champions League favourites, insists Bernardo Silva|
|Isco calls for Modric to win Ballon d´Or after Champions League win|
|Wawrinka into last eight in St Petersburg|
|Goal hero Pogba is one of the best in the world - Shaw|
|Sane SOS can´t salvage sorry City display|
|Hoffenheim will learn lessons from Shakhtar draw, insists Nagelsmann|
|Valencia 0 Juventus 2: Pjanic hits the spot after Ronaldo sees red|
|Viktoria Plzen 2 CSKA Moscow 2: Krmencik heroics undone by late show|
|Benfica 0 Bayern Munich 2: Sanches returns to haunt his former club|
|Young Boys 0 Manchester United 3: Pogba double inspires Red Devils|
|Manchester City 1 Lyon 2: Cornet and Fekir stun Champions League favourites at home|
|Real Madrid 3 Roma 0: Isco stunner sets up winning start for Champions League holders|
|Ronaldo sent off on Champions League debut for Juve and may miss United reunion|
|Shakhtar Donetsk 2 Hoffenheim 2: Maycon denies Nagelsmann´s side|
|Ajax 3 AEK Athens 0: Tagliafico at the double in opening win|
|Dalot makes debut, Martial starts for Manchester United|
|India avenge ICC Champions Trophy loss with big win over Pakistan|
|Ronaldo makes Champions League debut for Juve|
|Lopetegui picks Navas over Courtois for Champions League clash with Roma|
|Willian very happy under Sarri after Conte row|
|Sarri deals blow to Chelsea kids´ Europa League hopes|
|Mendy out for Manchester City as Aguero makes bench|
|Cech accepts performances key to securing Arsenal stay|
|Monchi rules out Spain return amid Barcelona rumours|
|Durham skittled for 61 and 66 on the same day|
|Kane isn´t a machine – Lamela defends misfiring Spurs star|
|Hazard left out of Chelsea squad for PAOK trip|
|Tiger feels close to ending drought after achieving Tour Championship goal|
|Leno in line for Arsenal chance in Europa League|
|Gazidis leaves Arsenal in good shape, insists Emery|
|Eagles bring back WR Matthews, place Wallace on IR|
|England include Stokes, Hales and uncapped seamer Stone in ODI squad|
|Suwon Bluewings 0 Jeonbuk Motors 3 (aet, 4-2 on penalties): Quarter-final comeback ends in spot-kick|
|Australia captain Paine ready to slog it out with Pakistan|
|Nadal pulls out of China Open & Shanghai Masters with knee injury|
|Ostapenko begins Korea Open defence with victory|
|Joshua v Povetkin: How Olympic super heavyweight champions have fared|
|Liverpool ´made a point´ with PSG victory - Gomez|