Frank Lampard knocked old boss Jose Mourinho out of the EFL Cup as Derby County beat Manchester United on penalties, while Burton Albion triumphed against Burnley.
Marouane Fellaini's late equaliser took Tuesday's tie to a shootout following a 2-2 draw at Old Trafford, with Scott Carson saving Phil Jones' poor penalty to complete a dramatic 8-7 success for the Championship side.
Harry Wilson and Jack Marriott had earlier struck for the Rams as Lampard enjoyed a memorable reunion with Mourinho, his manager at Chelsea.
United's rivals Manchester City made short work of League One side Oxford United as the holders progressed to the fourth round thanks to a 3-0 win.
Phil Foden helped to create goals for Gabriel Jesus and Riyad Mahrez before scoring his first goal for the club to wrap up a star performance.
Yeeeeeeessss @PhilFoden— Fernandinho (@fernandinho) September 25, 2018
Along with United's exit, the other big shock of the day came at Burton, where Burnley's awful cup competitions record under Sean Dyche continued with a 2-1 loss.
Kevin Long's header gave the Premier League team the lead, but League One Burton hit back through Liam Boyce, who then set up Jamie Allen for a late winner.
Penalties were needed in the all-Premier League tie at Molineux, with Danny Ward saving three spot-kicks after a goalless draw to book Leicester City a fourth-round berth at the expense of Wolves.
Go on the Warden Penalty saving masterclass @dan_ward52— James Maddison (@Madders10) September 25, 2018
Callum Wilson scored a 94th-minute winner to secure a 3-2 home victory for Bournemouth against Blackburn Rovers, while Andros Townsend struck twice as Crystal Palace won 3-0 at West Brom.
Jordan Rhodes' hat-trick booked Norwich City's progression with a 4-3 thriller at Wycombe Wanderers, with 15-year-old Harvey Elliott making his Fulham debut in their 3-1 win at Millwall.
Middlesbrough scored all four of their penalties to edge through in a shootout after drawing 2-2 with Preston North End, while Blackpool are in the last 16 after a 2-0 home win against 10-man QPR.
|Yankees send Sonny Gray to Reds|
|Ashley Cole reunited with Frank Lampard at Derby County|
|Arnold ready to mix things up in 2019 Asian Cup quarter-finals|
|Arum: Joshua desperately needs to fight in the United States|
|South Korea v Bahrain: Bento optimistic of continuing unblemished campaign|
|Bolton Wanderers 0 West Brom 2: Baggies bounce up to third after tennis ball protest|
|Confident Moeen ready to shine for England in the Caribbean|
|Juventus 3 Chievo 0: Allegri´s men cruise despite Ronaldo penalty save|
|Boateng completes shock Barcelona switch|
|United Arab Emirates 3 Kyrgyzstan 2 (after extra time): Khalil penalty sets up Socceroos showdown|
|West Indies add Drakes to new-look coaching team|
|Barcelona is a huge opportunity – Boateng confirms shock move is close|
|Donnarumma wishes Higuain luck ahead of expected Chelsea switch|
|Qatar v Iraq: Katanec anticipating ´huge challenge´ in last 16|
|Nuno hit with FA misconduct charge for pitch celebration|
|Furious Carreno Busta and Zverev bow out, Djokovic marches on|
|#NotMartinFromWakefield – Siewert shows viral sensation the door|
|Djokovic feeling the strain after late-night Medvedev battle|
|Henderson sidelined again ahead of Six Nations|
|Australia 0 Uzbekistan 0 (aet, 4-2 on penalties): Ryan heroics see holders hobble onwards|
|Halep exit leaves four-way fight to be crowned number one at Australian Open|
|Super Bowl-bound Rams set for London return, Chiefs to face Chargers in Mexico|
|Huddersfield appoint Siewert as Wagner´s replacement|
|Genoa 0 AC Milan 2: Borini and Suso step up with Higuain left out|
|McTominay signs new Manchester United contract|
|Pizzi to stand down after Saudi Arabia elimination|
|Boateng closing in on shock Barcelona switch - reports|
|Catalans to defend Challenge Cup after resolving RFL dispute|
|Djokovic wears down Medvedev to reach last eight|
|Mouratoglou: I knew ´loyal´ Serena would not fire me after US Open turmoil|
|Barcelona B defender Wague accuses Ejea fans of racist abuse|
|I felt like I had been hit by a train - Halep upbeat despite losing Serena battle|
|Arsenal confirm Mislintat departure|
|Icardi will renew, 100 per cent - Wanda Nara offers latest Inter assurance|
|Japan 1 Saudi Arabia 0: Four-time winners send Pizzi´s men out|
|A souvlaki maybe named after him, a growing fan base – Tsitsipas creating Melbourne buzz|
|Barca winger Dembele out for 15 days|
|Strikers blown away by Hurricanes in Adelaide|
|Ireland lose Beirne for England and Scotland clashes|
|´Innate fighter´ Serena says character key to beating Halep|
|Hudson-Odoi ´an outstanding talent´ - Bayern great Ballack hails Chelsea youngster|
|Scotland call up four as hand injury forces Watson out|
|Serena comes through major Halep battle to reach last eight|
|Better than Rafa? Camacho cameo leaves Klopp unconvinced by transfer options|
|England job ´a privileged position´, says Southgate|
|Emery has confidence in Arsenal outcast Ozil|
|Zverev destroys racquet in Aus Open meltdown|
|From Villarreal to Aus Open quarters – Bautista Agut breaks major duck|
|Brees: I plan on being here next year and making another run at it|
|´Unf******-believable bro!´ - Brady stunned after reaching third straight Super Bowl|
|New England find answers, penalty costs Kansas City – three takeaways from Patriots´ win over Chiefs|
|Donald Trump congratulates Brady and Super Bowl-bound Patriots|
|Rose helps Timberwolves down Suns|
|Brady leads Patriots into third straight Super Bowl|
|Osaka overcomes Sevastova to reach quarters|
|Chelsea remain behind Sarri – David Luiz|
|McVay explains Gurley´s limited role in Rams´ win over Saints|
|Southgate hails ´tremendous talent´ Rashford|
|Long earns maiden PGA Tour win at Desert Classic|
|Flanagan resigns as Sharks head coach|
|Rams´ Robey-Coleman admits he committed penalty on controversial no-call|
|NFL admits they blew the call – Saints coach Payton|
|Terrible no-call, Goff shines – three takeaways from Rams´ win over Saints|
|Lonzo Ball to miss 4-6 weeks with ankle sprain|
|Patterson added to Australia Test squad|
|Zuerlein´s overtime kick sinks Saints and sends Rams to Super Bowl|
|It was a clear goal – Valverde dismisses Barca VAR controversy|
|Rashford can emulate Man United greats Ronaldo and Rooney – Solskjaer|
|Karmichael Hunt swaps Reds for Waratahs|
|Barcelona forward Dembele set for tests on sprained ankle|